Ezrin mediates both HGF/Met autocrine and non-autocrine signaling-induced metastasis in melanoma
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چکیده
منابع مشابه
Autocrine PDGFR signaling promotes mammary cancer metastasis.
Metastasis is the major cause of cancer morbidity, but strategies for direct interference with invasion processes are lacking. Dedifferentiated, late-stage tumor cells secrete multiple factors that represent attractive targets for therapeutic intervention. Here we show that metastatic potential of oncogenic mammary epithelial cells requires an autocrine PDGF/PDGFR loop, which is established as ...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2017
ISSN: 0020-7136
DOI: 10.1002/ijc.31196